WJSC 6~(th) Anniversary Special Issues(2):Mesenchymal stem cells Brain mesenchymal stem cells:The other stem cells of the brain?

• 作者: Florence Appaix Marie-France Nissou Boudewijn van der Sanden Matthieu Dreyfus Franois Berger Jean-Paul Issartel Didier Wion
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: STEM CELL Mesenchymal STEM CELL PERICYTE BRAIN CELL plasticity Cancer STEM CELL GLIOMA NEURODEGENERATIVE disease
• 年，卷（期）: 2014,（2）
• 页码范围: 134-143
• 页数: 10页
• 分类号: R457.7

摘要

Multipotent mesenchymal stromal cells(MSC),have the potential to differentiate into cells of the mesenchymal lineage and have non-progenitor functions including immunomodulation.The demonstration that MSCs are perivascular cells found in almost all adult tissues raises fascinating perspectives on their role in tissue maintenance and repair.However,some controversies about the physiological role of the perivascular MSCs residing outside the bone marrow and on their therapeutic potential in regenerative medicine exist.In brain,perivascular MSCs like pericytes and adventitial cells,could constitute another stem cell population distinct to the neural stem cell pool.The demonstration of the neuronal potential of MSCs requires stringent criteria including morphological changes,the demonstration of neural biomarkers expression,electrophysiological recordings,and the absence of cell fusion.The recent finding that brain cancer stem cells can transdifferentiate into pericytes is another facet of the plasticity of these cells.It suggests that the perversion of the stem cell potential of pericytes might play an even unsuspected role in cancer formation and tumor progression.