New advances in the mesenchymal stem cells therapy against skin flaps necrosis

• 作者: Fu-Gui Zhang Xiu-Fa Tang
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: MESENCHYMAL stem CELLS Skin FLAPS ENDOTHELIAL PROGENITOR CELLS
• 年，卷（期）: 2014,（4）
• 页码范围: 491-496
• 页数: 6页
• 分类号: R329.2

摘要

Mesenchymal stem cells(MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various cells, such as osteoblasts, adipocytes, chondrocytes, vascular endothelial progenitor cells, and other cell types. MSCs are being widely studied as potential cell therapy agents due to their angiogenic properties, which have been well established by in vitro and in vivo researches. Within this context, MSCs therapy appears to hold substantial promise, particularly in the treatment of conditions involving skin grafts, pedicle flaps, as well as free flaps described in literatures. The purpose of this review is to report the new advances and mechanisms underlying MSCs therapy against skin flaps necrosis.