Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies

• 作者: Jian-Nan Li Kai Zhang Lan-Qing Cao Ning Liu Wei Li
• 来源期刊: 世界胃肠肿瘤学杂志:英文版(电子版)
• 学科: 医学
• 关键词: MESENCHYMAL stem cells GASTROINTESTINAL MALIGNANCIES Gastric CANCER HEPATOMA PANCREATIC CANCER Colorectal CANCER
• 年，卷（期）: sjwczlxzzywbdzb_2020,（4）
• 页码范围: 365-382
• 页数: 18页
• 分类号: R735

摘要

Mesenchymal stem cells(MSCs),which are a kind of stem cell,possess an immune privileged nature,tumour homing features,and multi-lineage differentiation ability.MSCs have been studied in many fields,such as tissue engineering,nervous system diseases,and cancer treatment.In recent years,an increasing number of researchers have focused on the effects of MSCs on various kinds of tumours.However,the concrete anticancer efficacy of MSCs is still controversial.Gastrointestinal(GI)malignancies are the major causes of cancerrelated death worldwide.The interactions of MSCs and GI cancer cells in specific conditions have attracted increasing attention.In this review,we introduce the characteristics of MSCs and analyse the effects of MSCs on GI malignancies,including gastric cancer,hepatoma,pancreatic cancer,and colorectal cancer.In addition,we also provide our perspectives on why MSCs may play different roles in GI malignancies and further research directions to increase the treatment efficacy of MSCs on GI malignancies.