Clinical Evaluation after Introduction of Stem Cell Supernatant Biocell Shot 65 by Electroporation

• 作者: Ryusuke Suzuki Harue Suzuki Maki Yokogawa Junichi Motohashi
• 来源期刊: 化妆品、皮肤病及应用期刊(英文)
• 学科: 医学
• 关键词: Clinical Evaluation Stem Cell Skin Treatment
• 年，卷（期）: hzppfbjyyqkyw_2021,（1）
• 页码范围: 58-70
• 页数: 13页
• 分类号: R73

摘要

<strong><span style="font-family:Verdana;">Objectives</span></strong><span style="font-family:Verdana;">:</span><span "=""><span style="font-family:Verdana;"> The objective of this study is clinical evaluation after introduction of stem cell supernatant Biocell Shot 65 by electroporation. </span><b><span style="font-family:Verdana;">Background:</span></b></span><span "=""><span style="font-family:Verdana;"> There is a clinical report of psoriasis treatment by umbilical cord blood-derived stem cells, in which there was a beneficial result. These clinical results are the result of cord blood-derived cell growth factors. The umbilical cord blood-derived stem cell culture supernatant contains a high amount of TGF-</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">, PDGA, etc., and promotes wound healing. In addition, we suppose </span><span style="font-family:Verdana;">that the supernatant has the esthetic effect of improving skin condition, thus,</span><span style="font-family:Verdana;"> we planned to make a clinical evaluation. However, it is difficult to set judgement criteria, and human judgement tends to be subjective. Therefore, in this study, as a new clinical evaluator, we used an AI skin diagnostic device with learning function. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Stem cell culture supernatant Biocell Shot 65 was used as an introduction solution. After it was applied to the full faces of four patients, electroporation with BeBe pinocchio DM-5 SUPER DX Plus promoted infiltration deep in the keratinized layer. The patients were all </span><span style="font-family:Verdana;">healthy women in their forties. This procedure was performed every two weeks</span><span style="font-family:Verdana;"> for three months. Wrinkles, fine lines around eyes, stains, pores, and 4V, </span><span style="font-family:Verdana;">which is considered as one diagnostic criteria, were evaluated at baseline</span><span style="font-fami