Modular Total Synthesis of(-)-Palmyrolide A and(+)-(5S,7S)-Palmyrolide A via Ring-Closing Metathesis and Alkene Isomerization

• 作者: Yecai Lai Wei-Min Dai
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 69-74
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202000458

摘要

A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.