RNA m6A meets transposable elements and chromatin

• 作者: Chenxi He Fei Lan
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2021,（12）
• 所属期刊栏目: COMMENTARY
• 页码范围: 906-910
• 页数: 5页
• 语种: 英文

摘要

N6-methyladenosine (m6A) is the most abundant internal chemical mark in eukaryotic messenger RNAs (mRNAs),regulating various processes in the life cycle of mRNA including splicing,nuclear export,degradation and transla-tion (reviewed in (Shi et al.,2019)).For decades,m6A has also been identified in non-coding RNAs including long non-coding RNAs (IncRNAs),small nuclear RNAs (snRNAs) and ribosomal RNAs (rRNAs) (Epstein et al.,1980;Maden,1986;Dominissini et al.,2012).Recently,several studies from different groups found that m6A occurred in chromatin associated regulatory RNAs (carRNAs),including promoter-associated RNA (paRNA),enhancer RNA (eRNA) and RNA transcribed from transposable elements (repeat RNA),which in tum influenced chromatin environment and transcription(Li et al.,2020;Liu et al.,2020,2021;Chen et al.,2021;Xu et al.,2021),through previously under-appreciated cross-talks between the m6A modification in RNA and epigenetics modifications in chromatin (Fig.1).Since the majority of these studies focused on the regulation of the transposable elements (TEs),especially in the context of repressive chromatin,the main part of this commentary will center on m6A and transcription silencing.