Looking back at the first twenty years of genomics

• 作者: John Quackenbush
• 来源期刊: 定量生物学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: FEATURE
• 页码范围: 6-16
• 页数: 11页
• 语种: 英文

摘要

Earlier this year,we celebrated the twentieth anniversary of the publication of the first draft human genome sequence—or more correctly,the nearly simultaneous publication of draft versions of the public human genome sequence and the private(Celera Genomics,Inc.)human genome sequence in Nature[1]and Science[2],respectively.Like many of the achievements of the Human Genome Project(HGP),the accomplishment was part scientific milestone,and part political compromise—in this case a"co-victory"brokered in hopes of ending the increasingly vitriolic exchanges in the press between the public and private projects ①.Not surprisingly,the publications generated their own controversies,with the groups arguing over which version of the genome sequence was"better."In some sense,the argument was ridiculous—Celera had its data as well as all the public data,which gave them a tremendous advantage in terms of assembling the sequences and resolving ambiguities.However,the public genome was freely available,could be downloaded and reanalyzed,and was obviously going to evolve and improve over time as more data became available.