Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan

• 作者: Abidou Kawalé Coulibaly Astrid Nawé Ngandeu Baly Ouattara Edmond Eti Estelle Megne Kouassi Jean Mermoz Djaha Marcel N’zué Kouakou Mariam Gbané-Koné
• 来源期刊: 风湿病与自身免疫疾病期刊(英文)
• 学科: 医学
• 关键词: Sub-Saharan Africa Systemic LUPUS ERYTHEMATOSUS Extractable Nuclear Anti-Antigens AUTOANTIBODIES Anti-Phospholipids AUTOANTIBODIES ELISA
• 年，卷（期）: 2015,（2）
• 页码范围: 28-35
• 页数: 8页
• 分类号: R5

摘要

Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients’ files with systemic lupus erythematosus aged 12 to 73 years old, who fulfilled the American College of Rheumatology (ACR)’s criteria. Antinuclear autoantibodies (ANA) were searched by indirect immunofluorescence. Anti-DNA native autoantibodies, extractable nuclear anti-antigens autoantibodies (anti-Sm, anti-SSA, anti-SSB and anti-RNP) and anti-phospholipids autoantibodies have been searched by ELISA technic. Results: The most frequent clinical manifestations were: articular damages (86.32%), cutaneous and mucosal lesions (71.79%) and fever (76.67%). Kidney damages have been noticed in 40.17%. Neurologic manifestations have been observed in 36.75%. Pericarditis and pleurisies have been noticed in 22.22% and 11.97% of cases, and anaemia in 86.32% of cases. ANA have been detected in 94.12% of cases, anti-DNA native’s autoantibodies in 73.53% and anti-Sm autoantibodies in 75% of cases. Anti-SSA and anti-SSB autoantibodies were respectively in 75% and 56.25% of cases. Anti-RNP autoantibodies were in all the patients, and anti-phospholipids autoantibodies were in 37.50% of cases. Conclusion: Systemic lupus erythematosus of Ivorian black subject is characterised by high prevalence of autoantibodies, mostly Anti-RNP.