Adult stem-like cells in kidney

• 作者: Keiichi Hishikawa Osamu Takase Masahiro Yoshikawa Taro Tsujimura Masaomi Nangaku Tsuyoshi Takato
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: STEM CELL Label-retaining CELLS rKS56 SPcells CD24 CD133 SCA-1 Induced PLURIPOTENT STEM ES CELL
• 年，卷（期）: 2015,（2）
• 页码范围: 490-494
• 页数: 5页
• 分类号: R

摘要

Human pluripotent cells are promising for treatmentfor kidney diseases, but the protocols for derivationof kidney cell types are still controversial. Kidneytissue regeneration is well confirmed in several lowervertebrates such as fish, and the repair of nephronsafter tubular damages is commonly observed after renalinjury. Even in adult mammal kidney, renal progenitorcell or system is reportedly presents suggesting thatadult stem-like cells in kidney can be practical clinicaltargets for kidney diseases. However, it is still unclearif kidney stem cells or stem-like cells exist or not. Ingeneral, stemness is defined by several factors suchas self-renewal capacity, multi-lineage potency andcharacteristic gene expression profiles. The definiteuse of stemness may be obstacle to understand kidneyregeneration, and here we describe the recent broadfindings of kidney regeneration and the cells thatcontribute regeneration.