A Meta-analysis of the association between different genotypes（G11778A, T14484C and G3460A ） of Leber hereditary optic neuropathy and visual prognosis

• 作者: Dong-Yu Guo Nan Hong Xia-Wei Wang Yang-Shun Gu
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: 2016,（10）
• 页码范围: 1493-1498
• 页数: 6页
• 分类号: R77

摘要

AIM:To analyze the influences of different genotypes(G11778A,T14484 C and G3460A) of Leber hereditary optic neuropathy(LHON) on visual prognosis. METHODS: After a systematic literature search,all relevant studies evaluating the association between the three primary mutations of LHON and visual prognosis were included.All statistical tests were calculated with Revman 5.2 and STATA 12.0. RESULTS: Ten independent studies were included finally.A significant association between the three primary mutations and prognostic vision over 0.3 were found in G11778 A versus T14484 C [odds ratio(OR) =0.10,95% confidence interval(CI) =0.05-0.17,P <0.001],G11778 A versus G3460A(OR=0.18,95%CI=0.09-0.37,P <0.001) and T14484 C versus G3460A(OR =2.45,95% CI =1.10-5.48,P <0.05).In addition,obtained by pairwise comparison,the vision during onset,age of onset and sex ratio of these three kinds of patients,have no statistical significance(P >0.05).CONCLUSION: From pairwise comparison,we conclude that these three different genotypes of LHON are related to patients' visual prognosis.The T14484 C patients might have a best prognostic vision,G3460 A second,and G11778 A worst.And there is little relation between the three different genotypes and patients' vision,age of onset and sex ratio.