2019 CNS Diseases: Advanced Diagnostics and Treatment Conference

• 来源期刊: 神经免疫与神经炎症（英文版）
• 年，卷（期）: 2019,（12）
• 所属期刊栏目: Meeting Abstracts
• 页码范围: 15-38
• 页数: 24页
• 语种: 英文

摘要

1. Yeast studies on the benefit of simvastatin in reducing levels of amyloid betaian Macreadie, Sudip Dhakal, Mishal Subhan, Ken Gardiner, Joshua Fraser RMIT University, Melbourne, Victoria, Australia A large-scale epidemiology study on statins previously showed that simvastatin was unique among statins in reducing the incidence of dementia. Since amyloid beta (Aβ42) is the protein that is most associated with Alzheimer's disease, this study has focused on how simvastatin influences the turnover of native Aβ42 and Aβ42 fused with green 昀uorescent protein (GFP), in the simplest eukaryotic model organism, saccharomyces cerevisiae. Previous studies have established that yeast constitutively producing Aβ42 fused to GFP offer a convenient means of analyzing yeast cellular responses to Aβ42.