Neural stem cells could serve as a therapeutic material forage-related neurodegenerative diseases

• 作者: Sarawut Suksuphew Parinya Noisa
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Alzheimer's DISEASE Huntington's DISEASE Neural stem cells Parkinson's DISEASE Cell therapy NEURODEGENERATIVE diseases
• 年，卷（期）: 2015,（2）
• 页码范围: 502-511
• 页数: 10页
• 分类号: R

摘要

Progressively loss of neural and glial cells is the keyevent that leads to nervous system dysfunctions anddiseases. Several neurodegenerative diseases, forinstance Alzheimer＇s disease, Parkinson＇s disease, andHuntington＇s disease, are associated to aging andsuggested to be a consequence of deficiency of neuralstem cell pool in the affected brain regions. Endogenousneural stem cells exist throughout life and are found inspecific niches of human brain. These neural stem cellsare responsible for the regeneration of new neurons torestore, in the normal circumstance, the functions of thebrain. Endogenous neural stem cells can be isolated,propagated, and, notably, differentiated to most celltypes of the brain. On the other hand, other types ofstem cells, such as mesenchymal stem cells, embryonicstem cells, and induced pluripotent stem cells can alsoserve as a source for neural stem cell production, thathold a great promise for regeneration of the brain. Thereplacement of neural stem cells, either endogenousor stem cell-derived neural stem cells, into impairedbrain is highly expected as a possible therapeutic meanfor neurodegenerative diseases. In this review, clinicalfeatures and current routinely treatments of agerelatedneurodegenerative diseases are documented.Noteworthy, we presented the promising evidence ofneural stem cells and their derivatives in curing suchdiseases, together with the remaining challenges toachieve the best outcome for patients.