Human dental pulp stem cells： Applications in futureregenerative medicine

• 作者: Pravin D Potdar and Yogita D Jethmalani
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Human dental PULP STEM CELLS Mesenchymalstem CELLS DENTIN PLURIPOTENCY STEM cell therapy Molecular MARKERS
• 年，卷（期）: 2015,（5）
• 页码范围: 839-851
• 页数: 13页
• 分类号: R

摘要

Stem cells are pluripotent cells, having a property ofdifferentiating into various types of cells of humanbody. Several studies have developed mesenchymalstem cells （MSCs） from various human tissues,peripheral blood and body fluids. These cells are thencharacterized by cellular and molecular markers tounderstand their specific phenotypes. Dental pulpstem cells （DPSCs） are having a MSCs phenotype andthey are differentiated into neuron, cardiomyocytes,chondrocytes, osteoblasts, liver cells and β cells of isletof pancreas. Thus, DPSCs have shown great potentialityto use in regenerative medicine for treatment of varioushuman diseases including dental related problems.These cells can also be developed into induced pluripotentstem cells by incorporation of pluripotencymarkers and use for regenerative therapies of variousdiseases. The DPSCs are derived from various dentaltissues such as human exfoliated deciduous teeth,apical papilla, periodontal ligament and dental follicletissue. This review will overview the information aboutisolation, cellular and molecular characterization anddifferentiation of DPSCs into various types of humancells and thus these cells have important applications inregenerative therapies for various diseases. This reviewwill be most useful for postgraduate dental students aswell as scientists working in the field of oral pathologyand oral medicine.