PKM2:a crucial neuroprotective target against oxidative stress

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Research Highlight
• 页码范围: 1432-1434
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmaa121

摘要

Recently,Yao et al.[1]firstly reported that glycolytic enzyme pyru-vate kinase M isoform 2(PKM2)represents a crucial antioxidant intermediate by driving glutathione(GSH)biosynthesis,thereby pro-tecting neurons from oxidative damage and conferring neuroprotec-tive effects.