Substrates for clinical applicability of stem cells

• 作者: Sanjar Enam Sha Jin
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Human PLURIPOTENT stem cells EXTRACELLULARMATRIX protein Synthetic substrate Peptide Polymer SCAFFOLD HYDROGEL
• 年，卷（期）: 2015,（2）
• 页码范围: 243-252
• 页数: 10页
• 分类号: R

摘要

The capability of human pluripotent stem cells （hPSCs）to differentiate into a variety of cells in the human bodyholds great promise for regenerative medicine. Manysubstrates exist on which hPSCs can be self-renewed,maintained and expanded to further the goal of clinicalapplication of stem cells. In this review, we highlightnumerous extracellular matrix proteins, peptide andpolymer based substrates, scaffolds and hydrogelsthat have been pioneered. We discuss their benefitsand shortcomings and offer future directions as well asemphasize commercially available synthetic peptidesas a type of substrate that can bring the benefits ofregenerative medicine to clinical settings.