Stem cell applications for pathologies of the urinary bladder

• 作者: Noha A Mousa, Hisham A Abou-Taleb, and Hazem Orabi
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: STEM CELLS Urinary bladder URETHRA Bladderreconstruction INCONTINENCE Cancer STEM CELLS Safety
• 年，卷（期）: 2015,（5）
• 页码范围: 815-822
• 页数: 8页
• 分类号: R

摘要

New stem cell based therapies are undergoing intenseresearch and are widely investigated in clinical fieldsincluding the urinary system. The urinary bladderperforms critical complex functions that rely on its highlycoordinated anatomical composition and multiplex ofregulatory mechanisms. Bladder pathologies resulting insevere dysfunction are common clinical encounter andoften cause significant impairment of patient＇s quality oflife. Current surgical and medical interventions to correcturinary dysfunction or to replace an absent or defectivebladder are sub-optimal and are associated with notablecomplications. As a result, stem cell based therapiesfor the urinary bladder are hoped to offer new venuesthat could make up for limitations of existing therapies.In this article, we review research efforts that describethe use of different types of stem cells in bladderreconstruction, urinary incontinence and retentiondisorders. In particular, stress urinary incontinence hasbeen a popular target for stem cell based therapiesin reported clinical trials. Furthermore, we discuss therelevance of the cancer stem cell hypothesis to thedevelopment of bladder cancer. A key subject thatshould not be overlooked is the safety and quality ofstem cell based therapies introduced to human subjectseither in a research or a clinical context.