Malaria modeling: In vitro stem cells vs in vivo models

• 作者: Florian Noulin
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: MALARIA Stem cells In VITRO MODELS ANIMAL MODELS HUMANIZED mice
• 年，卷（期）: 2016,（3）
• 页码范围: 88-100
• 页数: 13页
• 分类号: R531.3

摘要

The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. The malaria field is gaining new opportunities from this importantbreakthrough and novel tools were adapted and opened new frontiers for malaria research. In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models.