Changes of synaptic structures associated with learning, memory and diseases

• 作者: Ju Lu Yang Yang Yi Zuo
• 来源期刊: 临床转化神经医学(英文版)
• 学科: 医学
• 关键词: SYNAPTIC plasticity SPINE AXONAL bouton sensory DEPRIVATION LEARNING neurological disease multi-synaptic bouton multi-synaptic SPINE
• 年，卷（期）: 2018,（2）
• 页码范围: 99-117
• 页数: 19页
• 分类号: R338

摘要

Synaptic plasticity is widely believed to be the cellular basis of learning and memory. It is influenced by various factors including development, sensory experiences, and brain disorders. Long-term synaptic plasticity is accompanied by protein synthesis and trafficking, leading to structural changes of the synapse. In this review, we focus on the synaptic structural plasticity, which has mainly been studied with in vivo two-photon laser scanning microscopy. We also discuss how a special type of synapses, the multi-contact synapses(including those formed by multi-synaptic boutons and multi-synaptic spines),are associated with experience and learning.