In Vitro Antibacterial Activity of Galla Chinensis Combined with Different Antibacterial Drugs against Carbapenem-Resistant E.Coli

• 作者: Changzhi Xu Donglin Zhu Yanhua Yi Yun Xi Zhizhi Xie
• 来源期刊: 医学科学进展杂志(英文)
• 学科: 医学
• 关键词: Galla CHINENSIS Carbapenem resistance ESCHERICHIA COLI COMBINATION therapy
• 年，卷（期）: 2019,（4）
• 页码范围: 19-23
• 页数: 5页
• 分类号: R97

摘要

Objective:To evaluate the antibacterial effects of meropenem and levofloxacin respectively combined with Galla chinensis on carbapenem-resistant Escherichia coli in vitro.Methods:The protocol was designed with checkerboard method and the carbapenem-resistant E.coli was isolated in our hospital.The minimum inhibitory concentrations(MICs)of G.chinensis alone and combined with 2 antimicrobial agents against carbapenem-resistant E.coli were determined by broth dilution method and the fractional inhibitory concentration index(FICI)was calculated according to MICs results.Result:the combined use of G.chinensis and meropenem(or levofloxacin)significantly decreased both MIC50 and MIC90;After the combination of G.chinensis and meropenem,the synergistic effect was 86.7%,and the additive effect was 13.3%,no irrelevant and antagonistic effects.After combined use of G.chinensis and levofloxacin,the synergistic effect was 66.7%,and the additive effect was 33.3%.No irrelevant and antagonistic effects.Conclusion:Galla chinensis combined with meropenem or levofloxacin has synergistic and additive antibacterial effect,with certain combined antibacterial activity.