Lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis:A Randomized,Double-Blind,Placebo-Controlled,Pilot Clinical Trial

• 作者: Yang Liu Xinjie Yu Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Long Qian Qun Wang Zhengqing Xue Qixiao Zhai Wei Chen
• 来源期刊: 工程（英文）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Microecology—Article
• 页码范围: 376-385
• 页数: 10页
• 语种: 英文

摘要

Irritable bowel syndrome with diarrhea (IBS-D) is chronic intestinal dysfunction with diarrhea and other complicated clinical symptoms,and it has a great impact on the daily life and mental state of patients.Some studies have reported that ingestion of probiotics can significantly alleviate a variety of intestinal diseases.The purpose of this study was to investigate the IBS-D-alleviating effects of a probiotic strain,Lactobacillus plantarum (L.plantarum) CCFM8610,with multiple health-promoting effects.The study was a 12-week,randomized,double-blind,placebo-controlled,pilot clinical trial.Seventy-five patients were randomly assigned to receive the placebo,oligosaccharides,or L.plantarum CCFM8610 (1 × 1010 colony-forming units (CFU) per day),with a 2-week run-in period,an 8-week intervention period,and a 2-week follow-up observation period.The patients' clinical symptoms and quality of life were exam-ined by the IBS symptom severity scale (IBS-SSS) and the IBS quality of life scale (IBS-QOL).Changes in gut microbiota composition and diversity were measured at the end of the intervention period.The oral administration of L.plantarum CCFM8610 significantly decreased the IBS-SSS and IBS-QOL scores,reduced IBS-D symptom severity,recovered gut microbiota diversity,decreased the relative abundance of bloating-related genus Methanobrevibacter,and increased the relative abundance of butyric acid-producing genera,including Anaerostipes,Anaerotruncus,Bifidobacterium,Butyricimonas,and Odoribacter.These findings suggest that ingestion of L.plantarum CCFM8610 can significantly alleviate clinical symptoms and gut microbiota dysbiosis in IBS-D patients.The IBS-D-alleviating effect of L.plan-tarum CCFM8610 may be related to the increase in the relative abundance of butyric acid-producing gen-era in the intestine.