内皮源性缩血管因子花生四烯酸代谢物的作用多样性

• 作者: JI Xu KURAHASHI Kazuyoshi MURAKAMI Shizuka NISHIHASHI Tsuyoshi TRANDAFIR Cristina Corina WANG Ai-Min
• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 内皮 花生四烯酸 脑动脉 冠状血管
• 年，卷（期）: 2003,（11）
• 所属期刊栏目: 综述
• 页码范围: 1065-1069
• 页数: 5页
• 分类号: R9
• 语种: 英文

摘要

Vascular endothelium releases vasocontracting and/or vasorelaxing substances. Here, we report the diversity of endothelium-derived vasocontracting factors (EDCFs), arachidonic acid metabolites, and discuss the pathophysiological significance. In the canine basilar artery and the rabbit intrapulmonary artery, acetylcholine-induced contractions (Ach-induced EDC) are due to endothelial thromboxane A2 (TXA2) (TXA2-type). The Ach-induced EDC in the rabbit coronary artery is due to endothelial leukotrienes (LTs) (LTs-type). In addition, in the rat coronary artery, nicotine and noradrenaline (Nad)-induced EDCs are due to endothelial COX-metabolites (COX metabolite-type). These arachidonic acid metabolites derived from endothelium (activation by vasoactive substances including Ach, Nad and nicotine) cause a contraction of vascular smooth muscle cells and may disturb the local circulation. These EDCFs (TXA2, LTs and COX-metabolites) may be involved in the pathophysiology of cardiovascular immuno-inflammatory diseases.