Hepatic stem cells： A viable approach for the treatment ofliver cirrhosis

• 作者: Md Aejaz Habeeb, Sandeep Kumar Vishwakarma, Avinash Bardia, and Aleem Ahmed Khan
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: HEPATIC stem cells BIOENGINEERING LIVERCIRRHOSIS LABELING and TRACKING
• 年，卷（期）: 2015,（5）
• 页码范围: 860-865
• 页数: 6页
• 分类号: R

摘要

Liver cirrhosis is characterized by distortion of liverarchitecture, necrosis of hepatocytes and regenerativenodules formation leading to cirrhosis. Various typesof cell sources have been used for the managementand treatment of decompensated liver cirrhosis.Knowledge of stem cells has offered a new dimensionfor regenerative therapy and has been considered asone of the potential adjuvant treatment modality inpatients with end stage liver diseases （ESLD）. Humanfetal hepatic progenitor cells are less immunogenic thanadult ones. They are highly propagative and challengingto cryopreservation. In our earlier studies we havedemonstrated that fetuses at 10-18 wk of gestationage contain a large number of actively dividinghepatic stem and progenitor cells which possess bipotentnature having potential to differentiate intobile duct cells and mature hepatocytes. Hepatic stemcell therapy for the treatment of ESLD is in their earlystage of the translation. The emerging technologyof decellularization and recellularization might offera significant platform for developing bioengineeredpersonalized livers to come over the scarcity of desirednumber of donor organs for the treatment of ESLD.Despite these significant advancements long-termtracking of stem cells in human is the most importantsubject nowadays in order to answer several unsettlesissues regarding the route of delivery, the choiceof stem cell type（s）, the cell number and the timepointof cell delivery for the treatment in a chronicsetting. Answering to these questions will furthercontribute to the development of safer, noninvasive,and repeatable imaging modalities that could discoverbetter cell therapeutic approaches from bench to bedside.Combinatorial approach of decellularization andnanotechnology could pave a way towards the betterunderstanding in determination of cell fate posttransplantation.