Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis

• 作者: Bo Gong Chao Qu Ding-Ding Zhang Ping Shuai Rong Chen Xiao-Fang Huang Yi Shi Yu-Ping Liu Zi-Meng Ye
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: COL1A1 HIGH MYOPIA ASSOCIATION META-ANALYSIS
• 年，卷（期）: 2016,（8）
• 页码范围: 1187-1193
• 页数: 0页
• 分类号: R778.11

摘要

AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis.METHODS: All association studies on COL1A1 and high myopia reported up to June 10, 2014 in Pub Med,Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios(ORs) and 95%confidence intervals(95% CIs) were analyzed for singlenucleotide polymorphisms(SNPs) using fixed- and random- effects models according to between-study heterogeneity. Publication bias analyses were conducted by Egger’s test.RESULTS: A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model(CC vs CG+GG, P =0.03) and in heterozygous model(CG vs GG,P =0.04), but not in other models.CONCLUSION: This Meta-analysis shows that COL1A1 rs2269336(CC vs CG +GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association.