Applications of stem cells and bioprinting for potential treatment of diabetes

• 作者: Binata Joddar Monica Delgado Shweta Anil Kumar Victor E Mendez
• 来源期刊: 世界干细胞杂志:英文版(电子版)
• 学科: 医学
• 关键词: BIOPRINTING Tissue engineering Pluripotent STEM CELLS Mesenchymal STEM CELLS HUMAN embryonic STEM Adult HUMAN liver CELLS β-cells Islet CELLS Biomaterials Bioink STEM cell DIABETES
• 年，卷（期）: 2019,（1）
• 页码范围: 13-32
• 页数: 20页
• 分类号: R

摘要

Currently,there does not exist a strategy that can reduce diabetes and scientists are working towards a cure and innovative approaches by employing stem cellbased therapies.On the other hand,bioprinting technology is a novel therapeutic approach that aims to replace the diseased or lostβ-cells,insulin-secreting cells in the pancreas,which can potentially regenerate damaged organs such as the pancreas.Stem cells have the ability to differentiate into various cell lines including insulinproducing cells.However,there are still barriers that hamper the successful differentiation of stem cells intoβ-cells.In this review,we focus on the potential applications of stem cell research and bioprinting that may be targeted towards replacing theβ-cells in the pancreas and may offer approaches towards treatment of diabetes.This review emphasizes on the applicability of employing both stem cells and other cells in 3D bioprinting to generate substitutes for diseasedβ-cells and recover lost pancreatic functions.The article then proceeds to discuss the overall research done in the field of stem cell-based bioprinting and provides future directions for improving the same for potential applications in diabetic research.