In the paper,we study derivative estimates of the iterated spherical averages (At)N(f).We obtain the optimal range of exponents (α,N,p) to ensure the Lp boundedness of P((e)/(e)x)(A1)N(f)for 1 ≤ p ≤ ∞,where P is a homogeneous polynomial of degree α.The main theorem extends some known results.As an application,we obtain the smallest N such that (A1)N :Lp(Rn) → Lpα(Rn).