Asymmetric Catalytic[3+2]Annulation of Donor-Acceptor Cyclopropane with Cyclic Ketones:Facile Access to Enantioenriched 1-Oxaspiro[4.5]decanes

• 作者: Zhong-Bo Zheng Wen-Fu Cheng Lijia Wang Jun Zhu Xiu-Li Sun Yong Tang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Concise Reports
• 页码范围: 1629-1634
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202000277

摘要

A copper catalyzed enantioselective[3+2]annulation of donor-acceptor cyclopropanes with cyclic ke-tones has been developed,providing a concise protocol to enantioenriched 1-oxaspiro[4.5]decanes in up to 98％ yield with up to ＞99/1 dr and up to 92％ee.In addition,this method also provides a facile access to the enantioselective desymmetrisation of various 4-substituted cyclohexanones.The resulting products were easily converted to the core structures of two natural products Heliespirones A and halogenated sesquiterpene isolated from L.saitoi.