Imprinted Zac1 in neural stem cells

• 作者: Guillaume Daniel Udo Schmidt-Edelkraut Dietmar Spengler Anke Hoffmann
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Zac1 Cell FATE decisions Neural stem cells Genomic IMPRINTING Igf2-H19 DLK1 P57 Kip2 NECDIN Differentiation Imprinted gene networks
• 年，卷（期）: 2015,（2）
• 页码范围: 300-314
• 页数: 15页
• 分类号: R

摘要

Neural stem cells （NSCs） and imprinted genes playan important role in brain development. On historicalgrounds, these two determinants have been largelystudied independently of each other. Recent evidencesuggests, however, that NSCs can reset select genomicimprints to prevent precocious depletion of the stemcell reservoir. Moreover, imprinted genes like thetranscriptional regulator Zac1 can fine tune neuronalvs astroglial differentiation of NSCs. Zac1 binds ina sequence-specific manner to pro-neuronal andimprinted genes to confer transcriptional regulation andfurthermore coregulates members of the p53-familyin NSCs. At the genome scale, Zac1 is a central hub ofan imprinted gene network comprising genes with animportant role for NSC quiescence, proliferation anddifferentiation. Overall, transcriptional, epigenomic, andgenomic mechanisms seem to coordinate the functionalrelationships of NSCs and imprinted genes fromdevelopment to maturation, and possibly aging.