Vital roles of stem cells and biomaterials in skin tissueengineering

• 作者: Abu Bakar Mohd Hilmi Ahmad Sukari Halim
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: HAIR follicle stem cells Skin repair TISSUEENGINEERING CHITOSAN COLLAGEN
• 年，卷（期）: 2015,（2）
• 页码范围: 428-436
• 页数: 9页
• 分类号: R

摘要

Tissue engineering essentially refers to technologyfor growing new human tissue and is distinct fromregenerative medicine. Currently, pieces of skin arealready being fabricated for clinical use and manyother tissue types may be fabricated in the future.Tissue engineering was first defined in 1987 by theUnited States National Science Foundation whichcritically discussed the future targets of bioengineeringresearch and its consequences. The principles oftissue engineering are to initiate cell cultures in vitro ,grow them on scaffolds in situ and transplant thecomposite into a recipient in vivo . From the beginning,scaffolds have been necessary in tissue engineeringapplications. Regardless, the latest technology hasredirected established approaches by omitting scaffolds.Currently, scientists from diverse research institutesare engineering skin without scaffolds. Due to theiradvantageous properties, stem cells have robustlytransformed the tissue engineering field as part of anengineered bilayered skin substitute that will later bediscussed in detail. Additionally, utilizing biomaterialsor skin replacement products in skin tissue engineeringas strategy to successfully direct cell proliferation anddifferentiation as well as to optimize the safety ofhandling during grafting is beneficial. This approachhas also led to the cells＇ application in developing thenovel skin substitute that will be briefly explained in thisreview.