Advances in treatment of neurodegenerative diseases: Perspectives for combination of stem cells with neurotrophic factors

• 作者: Jie Wang Mei-Jiang Feng Wei-Wei Hu Zhi Jiang
• 来源期刊: 世界干细胞杂志:英文版(电子版)
• 学科: 医学
• 关键词: Neurodegenerative diseases Stem cells Brain-derived neurotrophic factor Glial cell line-derived neurotrophic factor Nerve growth factor Combination therapy
• 年，卷（期）: 2020,（5）
• 页码范围: 323-338
• 页数: 16页
• 分类号: R741

摘要

Neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease and amyotrophic lateral sclerosis,are a group of incurable neurological disorders,characterized by the chronic progressive loss of different neuronal subtypes.However,despite its increasing prevalence among the everincreasing aging population,little progress has been made in the coincident immense efforts towards development of therapeutic agents.Research interest has recently turned towards stem cells including stem cells-derived exosomes,neurotrophic factors,and their combination as potential therapeutic agents in neurodegenerative diseases.In this review,we summarize the progress in therapeutic strategies based on stem cells combined with neurotrophic factors and mesenchymal stem cells-derived exosomes for neurodegenerative diseases,with an emphasis on the combination therapy.