Aneuploidy in stem cells

• 作者: Jorge Garcia-Martinez Bjorn Bakker Klaske M Schukken Judith E Simon Floris Foijer
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: CHROMOSOMAL instability ANEUPLOIDY EMBRYONIC STEM CELLS Induced PLURIPOTENT STEM CELLS Mesenchymal STEM CELLS
• 年，卷（期）: 2016,（6）
• 页码范围: 216-222
• 页数: 7页
• 分类号: R

摘要

Stem cells hold enormous promise for regenerative medicine as well as for engineering of model systems to study diseases and develop new drugs. The discovery of protocols that allow for generating induced pluripotent stem cells (IPSCs) from somatic cells has brought this promise steps closer to reality. However, as somatic cells might have accumulated various chromosomal abnormalities, including aneuploidies throughout their lives, the resulting IPSCs might no longer carry the perfect blueprint for the tissue to be generated, or worse, become at risk of adopting a malignant fate. In this review, we discuss the contribution of aneuploidy to healthy tissues and how aneuploidy can lead to disease. Furthermore, we review the differences between how somatic cells and stem cells respond to aneuploidy.